Urinary Tract Toxicity in Rats Following Administration of β3-Adrenoceptor Agonists
نویسندگان
چکیده
منابع مشابه
Do β3-adrenoceptor agonists cause urinary bladder smooth muscle relaxation by inhibiting acetylcholine release?
Do β3-adrenoceptor agonists cause urinary bladder smooth muscle relaxation by inhibiting 1 acetylcholine release? 2 Focus on “Inhibition of cholinergic neurotransmission by β3-adrenoceptors depends on 3 adenosine release and A1 receptors activation in human and rat urinary bladder” 4 5 Katerina Okeke, Stavros Gravas, Martin C. Michel 6 7 8 Dept. of Pharmacology, Johannes Gutenberg University, M...
متن کاملEvaluation of Cardiopulmonary Toxicity Following Oral Administration of Multi-walled Carbon Nanotubes in Wistar Rats
Objective(s): Carbon nanotubes have unique mechanical, electrical, and thermal properties, with potential different applications in nanomedicine, electronics, and other industries. These new applications of carbon nanotubes in different industries lead to the increased exposure risk of nanomaterials to human. Up to now, all aspects of carbon nanotubes toxicity are not com...
متن کاملRelationship between expression of β3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms.
AIMS To investigate the relationship between urinary bladder mucosal expression of β3-adrenoceptor (AR) mRNA and urodynamic findings in patients with lower urinary tract symptoms and benign prostatic obstruction (BPO). METHODS During surgical prostate resection of 32 BPO patients, mucosal biopsies were collected and analyzed by reverse transcriptase polymerase chain reaction to determine the ...
متن کاملGastroprotective effects of β3-adrenoceptor agonists on water immersion plus restraint stress-induced gastric ulcer in rats
Objective: To evaluate the gastroprotective effects of β 3 -adrenoceptor agonists CGP 12177A and SR 58611A, on water immersion plus restraint stress (WIRS)-induced gastric ulceration in rats. Material and Methods: Drugs were administered (5, 10 and 15 mg/kg, p.o. ) 30 min prior to the ulcerogenic procedure. Ulcer index and the score for intensity of intraluminal bleeding were determined. Gastri...
متن کاملOn the Site and Mechanism of Action of β3-Adrenoceptor Agonists in the Bladder
The clinical success of mirabegron as the first β3-adrenoceptor (AR) agonist for treatment of the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and mechanism of action. Even if the adrenergic innervation of the bladder and urethra has been well studied, the location(s) of β3-ARs in different structures within the bladder wall and urethra, and the mode(s) of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1999
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339902700203